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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 485009Generated: November 1, 2026

Phosphorus oxychloride → Ethyl [2-(4-chlorophenyl)-5-pentyl-1,3-oxazol-4-yl]acetate

https://huagongshe.com/reaction/485009

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhosphorus oxychlorideHCID 24813—
ReactantEthyl 3-(4-chlorobenzamido)-4-oxononanoateHCID 13488805—
SolventDimethylformamideHCID 6228—
ProductEthyl [2-(4-chlorophenyl)-5-pentyl-1,3-oxazol-4-yl]acetateHCID 1348881284.3%

Reaction Steps

2.0 g of ethyl 3-(4-chlorobenzoylamino)-3-caproylpropionate, 10 ml of dimethylformamide and 1.0 g of phosphorus oxychloride are treated in the same manner as described in Example 1. 1.6 g of ethyl 2-[2-(4-chlorophenyl)-5-n-pentyl-4-oxazolyl]acetate are thereby obtained. Yield: 84.2%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04535089
Source datasetuspto-grants-1985_08
ORD IDord-d7e62a2776db4e668bd4782a54e66eab
Source noteuspto-grants-1985_08