Methanol → 2-[2-(4-Fluorophenyl)-5-isopropyl-4-oxazolyl]acetic acid

HRID 485011Notes

Reaction equation

HRID 485011 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH:19]([CH3:21])[CH3:20])=[C:11]([CH2:13][C:14]([O:16]CC)=[O:15])[N:12]=2)=[CH:4][CH:3]=1.CO.[OH-].[K+]>O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:9][C:10]([CH:19]([CH3:21])[CH3:20])=[C:11]([CH2:13][C:14]([OH:16])=[O:15])[N:12]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 13488808Ethyl 2-[2-(4-fluorophenyl)-5-isopropyl-4-oxazolyl]acetate

Product 1

HCID 134888152-[2-(4-Fluorophenyl)-5-isopropyl-4-oxazolyl]acetic acidYield 83.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2.0 g of ethyl 2-[2-(4-fluorophenyl)-5-isopropyl-4-oxazolyl]acetate, 15 ml of methanol, 5 ml of water and 0.8 g of potassium hydroxide are treated in the same manner as described in Example 8. 1.5 g of 2-[2-(4-fluorophenyl)-5-isopropyl-4-oxazolyl]acetic acid are thereby obtained. Yield: 83.3%.

Sources & evidence

ORD record
ord-d4b10cf0dcdc457f9b4aa1206ae9d2be
Source dataset
uspto-grants-1985_08
Patent number
US04535089

Reaction notes

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