HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-[2-(4-Fluorophenyl)-5-isobutyl-4-oxazolyl]acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Ethyl 2-[2-(4-fluorophenyl)-5-isobutyl-4-oxazolyl]acetate | HCID 13488810 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-[2-(4-Fluorophenyl)-5-isobutyl-4-oxazolyl]acetic acid | HCID 13488816 | 98.9% |
Reaction Steps
1.53 g of ethyl 2-[2-(4-fluorophenyl)-5-isobutyl-4-oxazolyl]acetate, 10 ml of methanol, 3 ml of water and 0.6 g of potassium hydroxide are treated in the same manner as described in Example 8. 1.37 g of 2-[2-(4-fluorophenyl)-5-isobutyl-4-oxazolyl]acetic acid are thereby obtained. Yield: 98.9%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04535089 |
| Source dataset | uspto-grants-1985_08 |
| ORD ID | ord-f181f53353264e0aa67969c5e4ac5183 |
| Source note | uspto-grants-1985_08 |