HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl bromoacetate → Ethyl 3-(4-fluorobenzoylamino)-3-isobutyrylpropionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | N-(4-fluorobenzoyl)isobutyrylmethylamine | HCID 13490306 | — |
| Product | Ethyl 3-(4-fluorobenzoylamino)-3-isobutyrylpropionate | HCID 14269213 | 90.2% |
Reaction Steps
5.6 g of N-(4-fluorobenzoyl)isobutyrylmethylamine, 1.2 g of 61% sodium hydride and 4.61 g of ethyl bromoacetate are treated in the same manner as described in Preparation 1-(5). 7.0 g of ethyl 3-(4-fluorobenzoylamino)-3-isobutyrylpropionate are thereby obtained as oil. Yield: 90.0%
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04535089 |
| Source dataset | uspto-grants-1985_08 |
| ORD ID | ord-67a04e1fce9945a1aa1d9b8298dab316 |
| Source note | uspto-grants-1985_08 |