Ethyl bromoacetate → HCID 20271337, compound

Participants

Reaction Steps

4.0 g of N-(4-fluorobenzoyl)isovalerylmethylamine are dissolved in 20 ml of dimethylsulfoxide and 1.3 g of potassium hydroxide are added thereto at 5° C. to 10° C. under vigorous stirring. The mixture is further stirred for 10 minutes. 3.1 g of ethyl bromoacetate are added dropwise to the mixture at the same temperature, and said mixture is further stirred for 2 hours. After the reaction, the mixture is treated in the same manner as described in Preparation 1-(5). 3.5 g of ethyl 3-(4-fluorobenzoylamino)-3-isovalerylpropionate are thereby obtained as oil. Yield: 64.8%.

Provenance & Evidence