HCID 13344847, compound → HCID 20271334, compound

Participants

Reaction Steps

2-(N-Methyl-2-propynylamino)-4-dimethylaminocarbonylthiazole (k) (474 mg) was dissolved in tetrahydrofuran (15 ml) and lithium aluminium hydride (250 mg) was added thereto at room temperature with stirring. The mixture was refluxed for 1 hour and, after decomposition of the excess lithium aluminium hydride with water, evaporated to remove the tetrahydrofuran. The residue was extracted with chloroform. The extract was washed with water, dried and evaporated to remove the solvent. The residue was applied to column chromatography on silica gel (10 g) to give 2-(N-methyl-2-propynylamino)-4-dimethylaminomethylthiazole (1) from chloroform-methanol (10:1) eluate as an oil (374 mg).

Provenance & Evidence