HCID 178489881, compound → HCID 178489882, compound

Participants

Reaction Steps

A solution of 3-(2-benzoyloxymethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole (37.1 g, 0.1 mole) in 10% NaOH (160 ml) and 95% ethanol (240 ml) is heated to 70° C. for one hour, then ethanol is distilled under vacuum and the reaction mixture is diluted with water (240 ml) and decolorized with activated carbon. The filtrate is brought to pH 8 by the addition of 10% HCl and stirred at room temperature for a few hours. The solid which separates is recovered by filtration and dried under vacuum yielding 24.2 g of 3-(2-hydroxymethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole. M.p. 155°-56° C.

Provenance & Evidence