Hydrochloric Acid → HCID 20271455, compound

Participants

Reaction Steps

Reaction of 3-amino-2-(4-aminobutyl)-5-methylpyridine from Example 1(d) (0.5 g) with sodium nitrite, cuprous chloride, copper bronze and hydrochloric acid under conditions analogous to those of Example 1(e) gave 3-chloro-2-(4-aminobutyl)-5-methylpyridine (0.43 g) as an oil. N.M.R. (CDCl3) assignment δ(p.p.m.), multiplicity; NH2, 1.56, s; CH2 (CH2)2CH2NH2, 1.4-1.9, m; 5--CH3, 2.29, s; --CH2NH2, 2.74, m; --CH2 (CH2)3NH2, 2.91, m; 4H+6H pyridyl protons, 7.45+8.24, m×2;

Provenance & Evidence