Lithium tri-tert-butoxyaluminohydride → HCID 20271506, compound

Participants

Reaction Steps

Dissolve the crude 8-methylthiodibenzo[b,f]thiepin-3-carboxylic acid chloride-5,5-dioxide in glyme, and with stirring under dry nitrogen, add a filtered solution of 1.1 equivalents of lithium tri-tertiary butoxy-aluminum hydride in glyme dropwise with cooling (ice-bath). Stir the mixture for 1 hour after the addition is complete and pour into ice-cold dilute hydrochloric acid. Isolate the crude title compound by extraction with chloroform and purify the compound by column chromatography on silica gel usin toluene as the solvent.

Provenance & Evidence