Ethanol → HCID 20271559, compound

Participants

Reaction Steps

6-Hydroxy-2-methoxy-3-n-propoxybenzaldehyde (5.25 g, 0.025 M), ethyl 5-brown pentanoate (3.96 ml, 0.025 M), anhydrous potassium carbonate (3.71 g). sodium iodide (0.15 g) and 95% ethanol (50 ml) were refluxed with stirring for 16 hr. The cooled reaction mixture was filtered and the solid washed well with ethanol. The filtrate was evaporated to dryness and the residue partitioned between ether and water. The organic layer was separated and washed with 2 N sodium hydroxide solution, water, dried (sodium sulphate) and evaporated to give ethyl 5-(2-formyl-3-methoxy-4-n-propoxyphenoxy)pentanoate as an oil.

Provenance & Evidence