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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 485174Generated: October 29, 2026

Sodium Iodide → 4-(2-Methyl-4-benzofuranyloxymethyl)benzonitrile

https://huagongshe.com/reaction/485174

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium IodideHCID 5238—
ReactantPotassium CarbonateHCID 11430—
Reactant4-(Bromomethyl)benzonitrileHCID 86996—
Reactant4-Hydroxy-2-methylbenzofuranHCID 12174561—
SolventEthanolHCID 702—
Product4-(2-Methyl-4-benzofuranyloxymethyl)benzonitrileHCID 13092104—

Reaction Steps

4-Hydroxy-2-methylbenzofuran (5.18 g, 0.035 M), 4-bromomethylbenzonitrile (6.86 g, 0.035 M), anhydrous potassium carbonate (5.2 g), sodium iodide (0.21 g) and 95% ethanol (50 ml) were reacted together in an analogous manner to that described in Example 5(A) to give 4-(2-methyl-4-benzofuranyloxymethyl)benzonitrile, m.p. 84°-85° C. (Found: C, 77.57; H, 5.02; N, 5.22. C17H13NO2 requires C, 77.55; H, 4.98; N, 5.32%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04535183
Source datasetuspto-grants-1985_08
ORD IDord-9e5dd4a6654d406faa33ddf26ea6557f
Source noteuspto-grants-1985_08