HCID 15582850, compound → HCID 15582870, compound

HRID 485206Notes

Reaction equation

HRID 485206 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12](=[O:13])[C:11]3[CH2:14][CH2:15][CH2:16][CH2:17][C:10]=3[C:9]2=[O:18])=[CH:4][C:3]=1[O:19][CH:20]([C:22]([O:24][CH2:25]C)=[O:23])[CH3:21]>CO>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12](=[O:13])[C:11]3[CH2:14][CH2:15][CH2:16][CH2:17][C:10]=3[C:9]2=[O:18])=[CH:4][C:3]=1[O:19][CH:20]([C:22]([O:24][CH3:25])=[O:23])[CH3:21]

Participants

3

Reactant 1

HCID 15582850HCID 15582850, compound

Product 1

HCID 15582870HCID 15582870, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 2.5 g. of N-[4-bromo-3-(1-ethoxycarbonylethyloxy)phenyl]-3,4,5,6-tetrahydrophthalimide in 30 ml. of methanol was prepared and HCl gas was bubbled at room temperature for 0.5 hour and then, the reaction mixture was kept for one night. The precipitate was separated by a filtration and washed with methanol to obtain 2.21 g. of Compound No. 16 shown in Table 1.

Workup

  1. customHCl gas was bubbled at room temperature for 0.5 hour
  2. waitthe reaction mixture was kept for one night
  3. customThe precipitate was separated by a filtration
  4. washwashed with methanol
  5. customto obtain 2.21 g

Sources & evidence

ORD record
ord-6072f0b7b5a94c049ed9e4a012155bb2
Source dataset
uspto-grants-1985_08
Patent number
US04536209

Reaction notes

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