HCID 20251544, compound → HCID 178445543, compound

HRID 485244Notes

Reaction equation

HRID 485244 reaction equation
[NH2:1][PH:2](=[O:4])[OH:3].BrCC(O[CH2:10][CH2:11][C:12]([CH3:15])([CH3:14])[CH3:13])=O>CC(=O)CC>[NH2:1][PH:2](=[O:3])[O:4][CH2:10][CH2:11][C:12]([CH3:15])([CH3:14])[CH3:13]

Participants

4

Reactant 2

HCID 20251544HCID 20251544, compoundHCID 178514660HCID 178514660, compound

Product 1

HCID 178445543HCID 178445543, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

A mixture of 4-(2-chloro-4-trifluoromethylphenoxy)-1,2-dinitrobenzene (2.15 g), α-amino-(n-propyl)methylphosphinic acid (1.63 g), K2CO3 (1.64 g) and DMSO (10 ml) is stirred at RT for one week and then poured into water and extracted with ether. The aqueous solution is acidified with dilute HCl and extracted with ether. The combined extracts are dried and evaporated to dryness to give the aminophosphinic acid (XVI; R is NO2, R1 is Me, R2 is H, R6 is Et, R5 is H, Y is Cl, Z is CF3). The aminophosphinic acid is reacted with neohexyl bromoacetate in 2-butanone under reflux to give neohexyl aminophosphinate (Compound 1, Table H).

Workup

  1. temperatureunder reflux

Sources & evidence

ORD record
ord-e35e171ca4a94c089014eaba31582317
Source dataset
uspto-grants-1985_08
Patent number
US04536355

Reaction notes

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