反应详情

A solution of 74 mg (0.295 mmol) of 4′-chlorospiro[1-azabicyclo[2.2.2]octane-3,2′(3′H)-furo[2,3-b]pyridine] in 10 mL of ethylenediamine was heated to reflux under a nitrogen atmosphere and stirred for 4 days. Upon cooling to ambient temperature, the solvent was removed in vacuo. The residue was dissolved in 20 mL of saturated aqueous sodium carbonate and extracted with chloroform (3×25 mL). The combined organic extract was dried over anhydrous magnesium sulfate and concentrated in vacuo to give the title compound as a dark oil, 80 mg (100%): electrospray MS (m/z, relative intensity) 275 ([MH]+).

1. temperatureto reflux under a nitrogen atmosphere
2. customthe solvent was removed in vacuo
3. dissolutionThe residue was dissolved in 20 mL of saturated aqueous sodium carbonate
4. extractionextracted with chloroform (3×25 mL)
5. extractionThe combined organic extract
6. dry with materialwas dried over anhydrous magnesium sulfate
7. concentrationconcentrated in vacuo