Foscarnet → HCID 23686684, compound

HRID 485285Notes

Reaction equation

HRID 485285 reaction equation
[O:1]([C:8]([P:10](=[O:22])([O:14][C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=1)[O:11]CC)=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Na+:23].[Na+].[Na+].OC(P(=O)(O)O)=O>>[O:1]([C:8]([P:10](=[O:11])([O-:22])[O:14][C:15]1[CH:16]=[CH:17][C:18]([Cl:21])=[CH:19][CH:20]=1)=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Na+:23]

Participants

4

Reactant 3

HCID 3415FoscarnetHCID 512103Phenyl (4-chlorophenoxy)(ethoxy)oxo-lambda~5~-phosphanecarboxylateHCID 16219045HCID 16219045, compound

Product 1

HCID 23686684HCID 23686684, compoundYield 36%

Procedure

From ethyl p-chlorophenyl phenoxycarbonylphosphonate. Yield 36%. T.l.c. Rf 0.54 single spot. By t.l.c. the compound was estimated to contain <0.2% of trisodium osycarbonylphosphonate. IR(KBr) cm-1 : 1710 (CO), 1490, 1270, 1090, 910. Preparation of monoesters of hydroxycarbonylphosphonic acid (of the phosphonic acid group).

Sources & evidence

ORD record
ord-f498fecfac8540e98a69b001dbe504de
Source dataset
uspto-grants-1985_08
Patent number
US04536400

Reaction notes

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