2-Furancarboxaldehyde, oxime → HCID 13520569, compound

HRID 485313Notes

Reaction equation

HRID 485313 reaction equation
C(=[N+]([O-])[CH:8]1[NH:13][C:12](=[O:14])[NH:11][C:10](=[O:15])[C:9]1([F:23])[C:16]([O:18][CH2:19][CH:20]([CH3:22])[CH3:21])=[O:17])C1OC=CC=1.[CH:25](=[N:31]/[OH:32])\[C:26]1[O:30][CH:29]=[CH:28][CH:27]=1>N1C=CC=CC=1.CC(C)=O>[F:23][C:9]1([C:16]([O:18][CH2:19][CH:20]([CH3:21])[CH3:22])=[O:17])[CH:8]([O:32]/[N:31]=[CH:25]/[C:26]2[O:30][CH:29]=[CH:28][CH:27]=2)[NH:13][C:12](=[O:14])[NH:11][C:10]1=[O:15]

Participants

4

Reactant 2

HCID 68712882-Furancarboxaldehyde, oximeHCID 86740255HCID 86740255, compound

Product 1

HCID 13520569HCID 13520569, compoundYield 55.1%

Reagents, catalysts & solvents 1

HCID 21978327HCID 21978327, compoundSolvent

Procedure

In 3 ml of pyridine-acetone (pyridine-acetone=2:1) were dissolved 341 mg (1 mmol) of N-(furfurylidene)-(5-fluoro-5-isobutoxycarbonyl-1,2,3,4,5,6-hexahydro-2,4-dioxopyrimidine-6-yl)amine N-oxide and 133 mg (1.2 mmol) of (E)-furfuraldoxime, and the solution was stirred at room temperature for 51 hours. The reaction solution was treated in the same manner as described in Example 9 to give 188 mg of isobutyl 5-fluoro-6-[(E)-furfurylideneaminooxy]-1,2,3,4,5,6-hexahydro-2,4-dioxopyrimidine-5-carboxylate.

Workup

  1. additionThe reaction solution was treated in the same manner

Sources & evidence

ORD record
ord-df0da4fb291b43cd8ff29809ea7a4db8
Source dataset
uspto-grants-1985_08
Patent number
US04536504

Reaction notes

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