HCID 13520517, compound → HCID 13520518, compound

Participants

Reaction Steps

A solution of 2.0 g (0.0054 mole) of N,N-dimethyl-2-(5-methyl-3-phenyl-4-isoxazolyl)-3-indole propionamide in 80 ml tetrahydrofuran is added to a suspension of 0.82 g (0.0216 mole) of lithium aluminum hydride in 40 ml tetrahydrofuran dropwise, maintaining the temperature between 20° and 25° C. After the addition is complete the mixture is stirred at room temperature for two hours, cooled and quenched by the addition of 2 ml of water in 20 ml tetrahydrofuran. The resulting mixture is dried over magnesium sulfate, filtered and evaporated. The solid residue is recrystallized from ethanol to give 2-(5-methyl-3-phenyl-4-isoxazolyl)-3-(3-dimethylaminopropyl)-indole m.p. 156° to 157° C.

Provenance & Evidence