HRID485332

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67136

1,3-Benzenedisulfonamide, 4-amino-6-chloro-

C6H8ClN3O4S2

结构：CCOC(=O)CCN(CC)C(=O)N1C[C@@H](Oc2ccc(C=COC)cc2)C[C@H]1C(=O)OCc1ccccc1

HCID131714306

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)CCN(CC)C(=O)N1C[C@@H](Oc2ccc(CC3Nc4cc(Cl)c(S(N)(=O)=O)cc4S(=O)(=O)N3)cc2)C[C@H]1C(=O)OCc1ccccc1

HCID131714307

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

2 次

PROCEDURE

实验过程

The diphenylmethyl ester product from part (c) in acetonitrile is reacted with a solution of 4-amino-6-chloro-1,3-benzenedisulfonamide in acetonitrile according to the procedure of 1(c) to give (cis)-4-[4-[[7-(aminosulfonyl)-6-chloro-3,4-dihydro-1,1-dioxo-2H-1,2,4-benzothiadiazin-3-yl]methyl]phenoxy]-1-[[(3-ethoxy-3-oxopropyl)ethylamino]carbonyl]-L-proline, phenylmethyl ester.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b27f5df39e9c47f89cf78463eb12c526
来源数据集: uspto-grants-1985_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04536501
来源说明: uspto-grants-1985_08

反应 SMILES

CO[CH:3]=[CH:4][C:5]1[CH:38]=[CH:37][C:8]([O:9][C@@H:10]2[CH2:14][N:13]([C:15]([N:17]([CH2:20][CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH2:18][CH3:19])=[O:16])[C@H:12]([C:27]([O:29][CH2:30][C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)=[O:28])[CH2:11]2)=[CH:7][CH:6]=1.[NH2:39][C:40]1[CH:45]=[C:44]([Cl:46])[C:43]([S:47]([NH2:50])(=[O:49])=[O:48])=[CH:42][C:41]=1[S:51]([NH2:54])(=[O:53])=[O:52]>C(#N)C>[NH2:50][S:47]([C:43]1[C:44]([Cl:46])=[CH:45][C:40]2[NH:39][CH:3]([CH2:4][C:5]3[CH:6]=[CH:7][C:8]([O:9][C@@H:10]4[CH2:14][N:13]([C:15]([N:17]([CH2:20][CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH2:18][CH3:19])=[O:16])[C@H:12]([C:27]([O:29][CH2:30][C:31]5[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=5)=[O:28])[CH2:11]4)=[CH:37][CH:38]=3)[NH:54][S:51](=[O:52])(=[O:53])[C:41]=2[CH:42]=1)(=[O:48])=[O:49]