反应详情

A solution of 1.0 g of 3-(3-hydroxypropyl)-N-(3-pyridyl)indole in 40 ml of dry pyridine at 0° is treated with 0.7 g of benzenesulfonyl chloride and stored at 0° for 14 hours. The solvent is evaporated and the residue is partitioned between ethyl ether and aqueous sodium bicarbonate solution. The organic phase is separated, dried over potassium carbonate and evaporated to yield crude N-(3-pyridyl)indole-3-propyl benzenesulfonate as an oil which is used without further purification.

1. customThe solvent is evaporated
2. customthe residue is partitioned between ethyl ether and aqueous sodium bicarbonate solution
3. customThe organic phase is separated
4. dry with materialdried over potassium carbonate
5. customevaporated