Sodium Hydroxide → HCID 13490361, compound

Participants

Reaction Steps

A solution of 1.0 g of 2-[4-(ethoxycarbonyl)butyl]-N-(3-pyridyl)indole and 0.25 g of sodium hydroxide in 5 ml of methanol and 5 ml of water is stirred for 17 hours at room temperature. The solvent is evaporated and the residue is redissolved in 10 ml of water and neutralized with 0.515 ml of concentrated hydrochloric acid. The resulting product is recrystallized from methanol to yield 2-(4-carboxybutyl)-N-(3-pyridyl)indole, m.p. 143°-144°.

Provenance & Evidence