反应详情

A solution of 5.0 g of 3-(4-carboxybutyl)-N-(3-pyridyl)indole in 50 ml of methanol is refluxed under nitrogen with 0.25 g of concentrated sulfuric acid for 2 hours. The reaction mixture is cooled and evaporated and partitioned between 50 ml of ether and 50 ml of ice-cold, saturated sodium bicarbonate solution. The organic phase is separated, dried over potassium carbonate and evaporated to yield 3-(4-methoxycarbonylbutyl)-N-(3-pyridyl)indole.

1. temperatureThe reaction mixture is cooled
2. customevaporated
3. custompartitioned between 50 ml of ether and 50 ml of ice-cold, saturated sodium bicarbonate solution
4. customThe organic phase is separated
5. dry with materialdried over potassium carbonate
6. customevaporated