Ethanolamine → HCID 20270197, compound

HRID 485359Notes

Reaction equation

HRID 485359 reaction equation
[CH2:1]([CH2:3][NH2:4])[OH:2].[C:5]([CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:14]([C:21]2[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=2)[CH:13]=1)(O)=O>>[O:2]1[CH2:1][CH2:3][N:4]=[C:5]1[CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:14]([C:21]2[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=2)[CH:13]=1

Participants

3

Reactant 2

HCID 700EthanolamineHCID 134903525-[1-(Pyridin-3-yl)-1H-indol-3-yl]pentanoic acid

Product 1

HCID 20270197HCID 20270197, compound

Procedure

A solution of 6.1 g of ethanolamine and 2.94 g of 3-(4-carboxybutyl)-N-(3-pyridyl)indole are heated at 170° for 3 hours. Excess ethanolamine is removed by distillation under reduced pressure to yield 3-[4-(4,5-dihydrooxazol-2-yl)butyl]-N-(3-pyridyl)indole.

Workup

  1. customExcess ethanolamine is removed by distillation under reduced pressure

Sources & evidence

ORD record
ord-f7371a9afd8b48aa8ee3fa8ca994edbb
Source dataset
uspto-grants-1985_08
Patent number
US04536505

Reaction notes

Loading…