Methanesulfonyl chloride → HCID 20270203, compound

Participants

Reaction Steps

A solution of 3.3 g of 3-hydroxymethyl-N-(3-pyridyl)indole in 25 ml of pyridine is cooled to +5° and 1.36 ml of methanesulfonyl chloride is added dropwise. After 3 hours the reaction is diluted with 75 ml of ice water and 1.5 g of sodium bicarbonate is added. Extraction with methylene chloride (3×25 ml) and drying of the extracts with sodium sulfate yields 3-(methanesulfonyloxymethyl)-N-(3-pyridyl)indole which is used directly in the next step.

Provenance & Evidence