HCID 20270201, compound → HCID 20270193, compound

Participants

Reaction Steps

A solution of crude 3-[(p-ethoxycarbonylphenoxy)methyl]-N-(3-pyridyl)-indole (6.5 g) in 60 ml of ethanol and 60 ml of 1N sodium hydroxide is heated under reflux for 3 hours. The ethanol is distilled off, the aqueous phase is washed with ether, acidified with conc. hydrochloric acid to pH=6, and the resulting solid is filtered off to yield 3-[(p-carboxyphenoxy)-methyl]-N-(3-pyridyl)indole. Treatment with ethanolic hydrogen chloride gives 3-[(p-carboxyphenoxy)methyl]-N-(3-pyridyl)indole hydrochloride.

Provenance & Evidence