3-(Dimethylaminomethyl)phenol → 4-[3-(1-Piperidinylmethyl)phenoxy]butanal

HRID 485377Notes

Reaction equation

HRID 485377 reaction equation
CN([CH2:4][C:5]1C=C(O)C=C[CH:10]=1)C.[CH3:12][N:13]([CH2:15][C:16]1[CH:17]=[C:18]([CH:25]=[CH:26][CH:27]=1)[O:19][CH2:20][CH2:21][CH2:22][CH:23]=[O:24])[CH3:14]>>[N:13]1([CH2:15][C:16]2[CH:17]=[C:18]([CH:25]=[CH:26][CH:27]=2)[O:19][CH2:20][CH2:21][CH2:22][CH:23]=[O:24])[CH2:14][CH2:10][CH2:5][CH2:4][CH2:12]1

Participants

3

Reactant 2

HCID 328963-(Dimethylaminomethyl)phenolHCID 20270275HCID 20270275, compound

Product 1

HCID 212975474-[3-(1-Piperidinylmethyl)phenoxy]butanal

Procedure

Similarly prepared from 3-[(dimethylamino)methyl]phenol (12.08 g) was 4-[3-[(dimethylamino)methyl]phenoxy]butanal (1.05 g) as a colourless oil b.p. 150°, 0.06 mm; tlc System A, Rf 0.59.

Sources & evidence

ORD record
ord-031152a212d94515801f409ba9503178
Source dataset
uspto-grants-1985_08
Patent number
US04536508

Reaction notes

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