Hydrazine hydrate (1:1) → HCID 178518139, compound

Participants

Reaction Steps

A solution of 3-[3-(1-piperidinylmethyl)phenoxy]propanamine (1.76 g) in tetrahydrofuran (70 ml) was treated with dimethyl N-methoxycarbonylcarbonimidodithioate (1.27 g) at room temperature, and the mixture was stirred for 6 h. Hydrazine hydrate (2 g) was added, and the mixture was heated under reflux for 18 h. The solution was evaporated, and the residue was chromatographed to give the title compound (250 mg) as a colourless oil. tlc. System B, Rf 0.5. Nmr (D2O) 2.5,t, (1H); 2.8-3.0,m,(3H); 5.72,s,(1H); 5.8,t, (3H); 6.5,m, (2H); 6.65,t, (2H); 7.05,br.t, (2H); 7.7-8.6,m, (8H).

Provenance & Evidence