1-{[3-(3-Aminopropoxy)phenyl]methyl}piperidin-4-ol → HCID 20270287, compound

Participants

Reaction Steps

Following the method of Example 17, N-[2-(acetyloxy)acetyl]-1-methyl-2-(phenylmethylene)hydrazinecarboximidothioate (0.75 g) and 3-[3-[1-(4-hydroxypiperidinyl)methyl]phenoxy]propanamine (0.65 g) gave 1-methyl-5-[[3-[3-[1-(4-hydroxypiperidinyl)methyl]phenoxy]propyl]amino]-1H-1,2,4-triazole-3-methanol (0.3 g), t.l.c. System B Rf 0.4. N.m.r. (CDCl3) 2.80,t,(1H); 3.0-3.3,m,(3H); 4.63,t,(1H); 5.52,s,(2H); 5.8-6.1,m,(5H); 6.3-6.7,m,(7H); 7.1-7.4,m,(2H) 7.7-8.7,m, (8H).

Provenance & Evidence