HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-oxo-6H-benzo[b][1]benzothiepine-2-carboxylic acid → 10,11-Dihydro-11-hydroxydibenzo[b,f]thiepin-3-carboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-oxo-6H-benzo[b][1]benzothiepine-2-carboxylic acid | HCID 827051 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Solvent | Sodium Bicarbonate | HCID 516892 | — |
| Product | 10,11-Dihydro-11-hydroxydibenzo[b,f]thiepin-3-carboxylic Acid | HCID 13151856 | 96.2% |
Reaction Steps
16.3 G. 10,11-dihydro-11-oxodibenzo-[b,f]thiepin-3-carboxylic acid is stirred in aqueous sodium bicarbonate solution and 5 g. sodium borohydride is added in portions. The foaming mixture is stirred for an additional half hour. The solution is extracted with ether and the aqueous layer acidified with hydrochloric acid and the solid filtered and dried to yield 15.8 g. of the desired yellow solid (96.2% yield), m.p. 202°-204° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04536507 |
| Source dataset | uspto-grants-1985_08 |
| ORD ID | ord-bd4a1abf95c9446891f8581486798769 |
| Source note | uspto-grants-1985_08 |