反应详情

550 Mg. 8-chloro-3-cyanodibenzo[b,f]-thiepin is refluxed for 16 hours in a mixture of 15 cc. acetic acid and 15 cc. 50% aqueous sulfuric acid. The reaction mixture is cooled down and the product filtered, washed with water and dried to yield 485 mg. (82% of the pure acid, m.p. 302°-304° C.

1. temperatureThe reaction mixture is cooled down
2. filtrationthe product filtered
3. washwashed with water
4. customdried
5. customto yield 485 mg