Acetic Acid → 8-Hydroxydibenzo[b,f]thiepin-3-carboxylic Acid-5-Oxide

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Reaction Steps

Suspend 100 mg. of the cyano compound of Step 2 in 5 ml. of acetic acid and 5 ml. of 20% aqueous sodium hydroxide. Reflux under nitrogen for 1 hour. Evaporate the alcohol and dilute the residue with water. Extract with ether and acidify the aqueous phase with 6N hydrochloric acid. Separate the solids by filtration. Dissolve the solids in ethanol and strip to dryness to obtain the title product (m.p., 288°-291° C. dec.).

Provenance & Evidence