HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 13490388, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 8-Fluoro-10-hydroxy-10,11-dihydrodibenzo[b,f]thiepin-3-carboxylic Acid | HCID 13490402 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 13490388 | HCID 13490388 | — |
Reaction Steps
Suspend 14.8 gm of the crude alcohol from Step C in 300 ml of glacial acetic acid and heat the mixture with stirring in an oil-bath at 110°-115° C. Add 50 ml of sulfuric acid in a thin stream. Continue stirring and heating for 15 minutes. Cool and pour into 500 ml of water. Separate the solids by filtration and stir at room temperature in 125 ml of ethylacetate overnight. Separate the solids by filtration to obtain the title product. (m.p. 273°-275° C.)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04536507 |
| Source dataset | uspto-grants-1985_08 |
| ORD ID | ord-2fcfd4ac44f245daa75b30cfff06902f |
| Source note | uspto-grants-1985_08 |