Hydrogen Peroxide → HCID 20270736, compound

Participants

Reaction Steps

221.3 Grams of 2-phenyl-3-(p-tolyl)-propionitrile (II-1), 40 g of a 25% aqueous sodium hydroxide solution, 291.5 g of a 35% aqueous hydrogen peroxide solution and 2.78 g of tetra-n-butylammonium chloride were mixed at 50° C. for 4 hours in 663.9 g of methanol. After the reaction was completed, methanol was distilled off and the formed precipitate was filtered out and washed with water to obtain 234.5 g of 2-phenyl-3-(p-tolyl)-propionamide (m.p.: 150°-151° C.) (I-1) in a yield of 98%.

Provenance & Evidence