Sodium Hydroxide → HCID 70039904, compound

Participants

Reaction Steps

Dibenzylphosphory-L-alanyl-N-(2-indanyl) glycyl-L-proline methylester (0.79 g, 1.2 m mole) was dissolved in acetone (5 ml), and sodium hydroxide (0.15 g, 3.8 m mole) in water (4 ml) solution was added thereto while cooling in the ice bath. The mixture was stirred for 1 hour. To the solution water (100 ml) was added, and thereafter it was washed with ethyl ether (50 ml). It was neutralized with 1N hydrochloric acid, and therefrom the desired product was extracted with ethyl acetate. Thus extracted solution was dried with anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure to obtain an oily dibenzylphosphoryl-L-alanyl-N-(2-indanyl) glycyl-L-proline (0.77 g, yield: 99.7%).

Provenance & Evidence