Dimedone → HCID 178428472, compound

Participants

Reaction Steps

A mixture of 2-ethoxy-4-methyl-3,4,5,6-tetrahydropyridine (9.27 grams, 0.066 mole) and dimedone (9.20 grams, 0.066 mole) is heated at 112°-113° C. for a 3-hour period. The cooled residue is dissolved in ethyl ether and extracted with three portions of 3N HCl. A solution of 6N sodium hydroxide is added to the strongly acidic solution causing the product to separate as a white solid, with precipitation complete at a final pH of 1. The crude product weighs 4.32 grams on drying and melts at 172°-175° C. Recrystallization from a large volume of cyclohexane gives 2.64 grams of pure material, m.p. 174° C.

Provenance & Evidence