HCID 20268362, compound → HCID 20268359, compound

HRID 485611Notes

Reaction equation

HRID 485611 reaction equation
[F:1][C:2]([F:17])([O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[N+:14]([O-])=O)[C:3]([F:6])([F:5])[F:4].[H][H]>[Ni].O1CCOCC1>[F:1][C:2]([F:17])([O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[NH2:14])[C:3]([F:4])([F:6])[F:5]

Participants

5

Reactant 2

HCID 20268362HCID 20268362, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20268359HCID 20268359, compoundYield 85.3%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 312751,4-DioxaneSolvent

Procedure

A mixture of 27.2 g of crude 2-pentafluoroethoxy-nitrobenzene, 2.6 g of Raney-nickel catalyst and 250 ml of dioxane is agitated in a hydrogen atmosphere for 24 hours at a temperature of 20°-25° C. The hydrogen consumption is 6.54 liters. After filtering off the catalyst, the solution is evaporated to dryness, yielding 20.5 g of 2-pentafluoroethoxy-aniline in form of a yellowish oil.

Workup

  1. customThe hydrogen consumption
  2. filtrationAfter filtering off the catalyst
  3. customthe solution is evaporated to dryness

Sources & evidence

ORD record
ord-fde53f9dddd0461ebe23f164a473a730
Source dataset
uspto-grants-1985_08
Patent number
US04537619

Reaction notes

Loading…