反应详情

5-Bromo-2-(4-aminobutyl)-3-methylpyridine, (0.73 g), was fused with 2-methylthio-5-(4-chlorobenzyl)-4-pyrimidone (0.75 g) at 160°-170° C. and heating was continued for 6 hours. The mixture was cooled and recrystallised from chloroform/petroleum-ether (b.p. 60°-80° C.), to give 2-[4-(3-methyl-5-bromopyrid-2-yl)butylamino]-5-(4-chlorobenzyl)-4-pyrimidone (1.0 g) m.p. 149°-150° C.

1. temperatureheating
2. temperatureThe mixture was cooled
3. customrecrystallised from chloroform/petroleum-ether (b.p. 60°-80° C.)