Acetic Anhydride → HCID 13338728, compound

HRID 485666Notes

Reaction equation

HRID 485666 reaction equation
[OH:1][CH:2]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[NH:8][C:7](=[O:15])[CH2:6][CH2:5][CH2:4][CH2:3]1.[C:16](OC(=O)C)(=[O:18])[CH3:17]>>[C:16]([O:1][CH:2]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[NH:8][C:7](=[O:15])[CH2:6][CH2:5][CH2:4][CH2:3]1)(=[O:18])[CH3:17]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 133387277-Hydroxy-1,3,4,5,6,7-hexahydro-2H-1-benzazonin-2-one

Product 1

HCID 13338728HCID 13338728, compound

Procedure

A solution of 7-hydroxy-1,3,4,5,6,7-hexahydro-1-benzazonin-2-one (9.2 g) in acetic anhydride (200 ml) is maintainwed at 80° for 3 hours. The reaction mixture is cooled to room temperature and the solvents removed under reduced pressure. Ether (300 ml) is added, and the resulting solution washed with water (150 ml) and dried over magnesium sulfate. The solvent is removed under reduced pressure to give 7-acetoxy-1,3,4,5,6,7-hexahydro-1-benzazonin-2-one.

Workup

  1. customthe solvents removed under reduced pressure
  2. additionEther (300 ml) is added
  3. washthe resulting solution washed with water (150 ml)
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-9e73721a5ab1448185b08ffb843bb62c
Source dataset
uspto-grants-1985_08
Patent number
US04537885

Reaction notes

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