Sodium Hydroxide → HCID 10559871, compound

Participants

Reaction Steps

A solution of 45.26 g of the product of Step A, 50 ml of 2N sodium hydroxide solution and 450 ml of acetone was stirred for 6 hours at 20° C. and was evaporated to dryness. The residue was added to water and ether and the decanted aqueous phase was extracted with ether. The combined organic phases were evaporated to dryness under reduced pressure and the residue was chromatographed over silica gel. Elution with a 4-1 hexane-ethyl acetate mixture yielded 28.75 g of tert.-butyl (1R,trans) 2,2-dimethyl-3-formyl-cyclopropane-carboxylate.

Provenance & Evidence