反应详情

To a solution of 1-[(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl]-pyrimidin-acetic acid ethyl ester (1.4 g, 2.75 mmol) in a mixture dioxane/MeOH (4/3) (35 ml) was added dropwise 2M NaOH(aq) (24 ml). The resulting mixture was stirred at RT for 20 h under nitrogen. The mixture was then concentrated in vacuo, combined with water and AcOEt. The aqueous phase was acidified until pH 1 with 2N HCl, extracted three times with with CH2Cl2, the combined organic phases were dried over anhydrous MgSO4, filtered and concentrated to give the titled product (1.23 g, 93%) as yellow-green crystals.

1. concentrationThe mixture was then concentrated in vacuo
2. extractionextracted three times with with CH2Cl2
3. dry with materialthe combined organic phases were dried over anhydrous MgSO4
4. filtrationfiltered
5. concentrationconcentrated