反应详情

2-Phenylpropionic acid (8.4 g, 56 mmol) in methanol (180 ml) and concentrated H2SO4 (2 ml) were heated at reflux for 4 hours. The reaction was cooled down to room temperature and concentrated in vacuo (~30 ml), which was poured into ice water (~100 ml). The products were extracted with Et2O (150 ml×3), which was washed with saturated NaHCO3, H2O and dried over MgSO4. Filtration and evaporation of solvent yielded a yellow oil (8.9 g), which was distilled to give a colorless oil (8.34 g, 51 mmol, 91%, b.p. 73° C./1.5 mm Hg).

1. temperatureat reflux for 4 hours
2. concentrationconcentrated in vacuo (~30 ml), which
3. additionwas poured into ice water (~100 ml)
4. extractionThe products were extracted with Et2O (150 ml×3), which
5. washwas washed with saturated NaHCO3, H2O
6. dry with materialdried over MgSO4
7. filtrationFiltration and evaporation of solvent