N-Methylisatoic anhydride → HCID 178482124, compound

HRID 485757Notes

Reaction equation

HRID 485757 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[OH:11].[CH3:12][N:13]1C(=O)O[C:16](=[O:17])[C:15]2=[CH:21][CH:22]=[CH:23][CH:24]=[C:14]12>>[CH3:12][NH:13][C:14]1[CH:24]=[CH:23][CH:22]=[CH:21][C:15]=1[C:16]([N:7]1[C:8]2[C:4](=[CH:3][C:2]([Cl:1])=[CH:10][CH:9]=2)[C:5]([OH:11])=[N:6]1)=[O:17]

Participants

3

Reactant 2

HCID 25160N-Methylisatoic anhydrideHCID 178518959HCID 178518959, compound

Product 1

HCID 178482124HCID 178482124, compoundYield 32.3%

Procedure

5-Chloro-1H-indazol-3-ol was reacted with N-methylisatoic anhydride according to the general procedure A above and afforded the desired amine as a yellow solid in 32.3% yield; m.p. 206°-208° C.

Sources & evidence

ORD record
ord-f072ba8d7dc3408d9243009eea95db7a
Source dataset
uspto-grants-1985_08
Patent number
US04537966

Reaction notes

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