HCID 178482126, compound → HCID 178482125, compound

Participants

Reaction Steps

To 1.5 g. of 1-(2-methylaminobenzoyl)-5-nitro-1H-indazol-3-ol, prepared in Example 19, suspended in 500 ml. of absolute EtOH was added 1.0 g. of 5% Pd/C and the mixture was hydrogenated at 50 psi for 20 hours. The catalyst was filtered off, washed with absolute EtOH and the filtrate evaporated to afford a semi-solid. Recrystallization from EtOH afforded 0.48 g. (35.4%) of the amine as a tan amorphous powder; mp. 169°-170° C.

Provenance & Evidence