1,2-Ethanediamine, 4-methylbenzenesulfonate (1:?) → HCID 13281188, compound

Participants

Reaction Conditions

Reaction Steps

A mixture containing 4-(2-cyanoethyl)-1-piperidinecarboxaldehyde (10 g, 0.06M) and ethylenediamine p-toluenesulfonate (30 g, 0.129M) were heated at 200° C. for 41/2hours. Crystallization of the crude reaction mixture from isopropanol (70 ml) yielded the desired product as the di-p-toluenesulfonate salt (14 g). The salt was then basified with 2 equivalents of MeONa and distilled (0.2 mmHg, 170° C.) to give 4-[2-(4,5-dihydro-1H-imidazol-2-yl)ethyl]piperidine (4.1 g, 37% yield).

Provenance & Evidence