反应详情

2-(3-pyridyl)imidazoline (7.2 g, 0.049M), and barium manganate (52.5 g) in CH2Cl2 (500 ml) were refluxed for 24 hrs. The reaction mixture was then filtered through diatomaceous earth, washed with ethylacetate (3×200 ml) and methanol (3×100 ml). The combined filtrates were concentrated to yield an oil which was purified on silica gel column, eluted with 20% by volume methanol 80% by volume methylene dichloride, to give 3-(1H-imidazol-2-yl)pyridine (4.66 g, 64.7%).

1. filtrationThe reaction mixture was then filtered through diatomaceous earth
2. washwashed with ethylacetate (3×200 ml) and methanol (3×100 ml)
3. concentrationThe combined filtrates were concentrated
4. customto yield an oil which
5. customwas purified on silica gel column
6. washeluted with 20% by volume methanol 80% by volume methylene dichloride