Water → HCID 20269145, compound

Participants

Reaction Steps

2.6 g (0.01 mole) of N-2-amino-benzyl-1-phenyl-2-methyl-amino-1-ethanol are dissolved in 30 ml of ether. To the solution 0.79 g (0.01 mole) of anhydrous pyridine are added, whereupon 1.3 g (0.012 mole) of ethyl chloroformate are added under vigorous stirring and cooling and the reaction is carried out at 15° C. The reaction mixture which contains a white precipitate is stirred at room temperature for 330 minutes, poured into 30 ml of icecold water, the aqueous phase is extracted three times with 100 ml of ether each, the united ether extracts are dried over anhydrous sodium sulfate and evaporated in vacuo. Thus 2.8 g of N-[2-ethoxycarbonylamino-benzyl]-1-phenyl-2-methyl-amino-1-ethanol are obtained in the form of a yellowish-white oil which can be subjected to further reaction without purification.

Provenance & Evidence