p-(1-Trifluoromethylheptyloxy)nitrobenzene → p-(1-Trifluoromethylheptyloxy)-aniline

HRID 485985Notes

Reaction equation

HRID 485985 reaction equation
[F:1][C:2]([F:21])([F:20])[CH:3]([O:10][C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=1)[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[H][H]>[Pd].C(O)C>[F:1][C:2]([F:20])([F:21])[CH:3]([O:10][C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=1)[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

Participants

5

Reactant 2

HCID 15123947p-(1-Trifluoromethylheptyloxy)nitrobenzeneHCID 178418361HCID 178418361, compound

Product 1

HCID 15123948p-(1-Trifluoromethylheptyloxy)-aniline

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To 100 ml of dry ethanol containing 77.7 g of oa p-(1-trifluoromethyl-heptyloxy)-nitrobenzene, was added 0.5 g of 5% Pd/C (5% palladium carbon) followed by carrying out reduction within an atmosphere of hydrogen at normal pressure under stirring at room temperature. After it was confirmed that no absorption of hydrogen was observed, the catalyst was removed by filtration and then the ethanol was distilled off to obtain 6.7 g of oily oa p-(1-trifluoromethylheptyloxy)-aniline.

Workup

  1. customAfter it was confirmed that no absorption of hydrogen
  2. customthe catalyst was removed by filtration
  3. distillationthe ethanol was distilled off

Sources & evidence

ORD record
ord-bd92b8dd6add4baaa6f77ebbbb3a8fef
Source dataset
uspto-grants-1994_03
Patent number
US05290478

Reaction notes

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