HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 485991Generated: October 30, 2026
Dimethylformamide → 5-Methoxy-2-(4-benzyloxyphenyl)pyrimidine
https://huagongshe.com/reaction/485991
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Benzyl Chloride | HCID 7503 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Methoxy-2-(4-hydroxyphenyl)pyrimidine | HCID 135736941 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Methoxy-2-(4-benzyloxyphenyl)pyrimidine | HCID 19097060 | 64.7% |
Reaction Steps
A mixture of 9.0 g of 5-methoxy-2-(4-hydroxyphenyl)pyrimidine, 8.45 g of benzyl chloride, 270 ml of dimethylformamide (DMF), and 12.3 g of potassium carbonate was stirred at 80° C. for 4 hours. The reaction mixture was diluted with water and extracted with ethyl acetate. The extract was washed with water and distilled to remove ethyl acetate to obtain 8.42 g (percent yield: 64.2%) of 5-methoxy-2-(4-benzyloxyphenyl)pyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05290477 |
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| Source dataset | uspto-grants-1994_03 |
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| ORD ID | ord-d6fcca4f37c54d1d96d3954441d8c3e1 |
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| Source note | uspto-grants-1994_03 |
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