HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 5-[3-(R)-fluoroheptyloxy]-2-(4-hydroxyphenyl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 5-[3-(R)-fluoroheptyloxy]-2-(4-benzyloxyphenyl)pyrimidine | HCID 22850597 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-[3-(R)-fluoroheptyloxy]-2-(4-hydroxyphenyl)pyrimidine | HCID 136378372 | 102% |
Reaction Steps
A mixture of 1.41 g of 5-[3-(R)-fluoroheptyloxy]-2-(4-benzyloxyphenyl)pyrimidine, 0.22 g of 10palladium-on-carbon, 14 ml of methanol, and 14 ml of tetrahydrofuran (THF) was kept at 30° C., and hydrogen gas was blown thereinto over 6 hours with stirring. The catalyst was removed by filtration, and the solvent was removed by distillation to obtain 1.11 g of 5-[3-(R)-fluoroheptyloxy]-2-(4-hydroxyphenyl)pyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05290477 |
| Source dataset | uspto-grants-1994_03 |
| ORD ID | ord-4e601c077c634208a8552f3a2a48a370 |
| Source note | uspto-grants-1994_03 |