HCID 19097417, compound → HCID 19097409, compound

Participants

Reaction Steps

A mixture of ethyl 3,4,8-trimethyl-2-(phenylmethyl)-2-azabicyclo[2.2.2]-oct-7-ene-6-carboxylate hydrochloride (26.2 g, 75 mmol), 10% palladium on carbon (2.6 g) and ethanol (200 mL) were placed on a Parr hydrogenator at 50 psi for 3.5 hours. The catalyst was removed by filtration and the solvent was removed in vacuo to afford crude ethyl 3,4,8-trimethyl-2-azabicyclo[2.2.2]-octane-6-carboxylate hydrochloride as a yellow oil, which was used directly in the next step.

Provenance & Evidence