Acetic Anhydride → HCID 10469565, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve 50 grams (0.2 mol) of (6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)carboxylic acid in 150 cm3 of anhydrous pyridine. Add dropwise 9.4 cm3 (0.1 mol) of acetic anhydride under a stream of nitrogen. Stir for 2 hours at a temperature of 30° C. After cooling, pour the mixture onto some ice, extract the resulting product with diethyl ether, and wash the organic phase with a 0.2N hydrochloric acid solution, and then with water until neutral. After evaporation of the solvent, an oily mass is collected which crystallises after trituration in diisopropyl ether.

Provenance & Evidence